Environmental Microbial Exposure and Protection against Asthma
环境微生物暴露对哮喘的保护作用
10.1056/NEJMcibr1511291 2015-12-24, Editorial Material [IF:91.245]
Lipopolysaccharide levels in household dusts are inversely related to the prevalence of allergy in urban children, a finding consistent with the protective effect of exposure to lipopolysaccharides. A new study describes a molecular pathway that may underpin this effect.
①哮喘发病通常始于婴儿时期;
②在传统农场环境下长大的北欧孩子对哮喘及过敏有天然抵抗力;
③农场环境下的尘埃中含有的大量细菌LPS可能介导产生这种天然抵抗力;
④城市中长大的孩子家中尘埃的LPS含量与其哮喘发病风险呈相反关系;
⑤需要进一步研究揭示这种相关性的背后机制。